This compound was also examined for mu-opioid receptor action, and like conolidine, was uncovered to possess no action at the location. Employing exactly the same paw injection examination, quite a few alternatives with higher efficacy were found that inhibited the initial suffering response, in

Preliminary research point out conolidine may well inhibit certain ion channels, decreasing neuronal excitability and limiting suffering indicators. This system is particularly suitable in neuropathic agony, where irregular signaling brings about persistent discomfort. On top of that, conolidine